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Title   재발의 위험이 높은 표재성 방광종양에서 Mitomycin C 와 Bacillus Calmette - Guerin 의 예방적 효과 : 단기추적에서의 비교 ( Mitomycin C Vs Bacillus Calmette - Guerin : Comparison of Prophylactic Efficacy to High Risk Superficial Bladder Tumor )
Publicationinfo   1991 Jan; 023(01): 101-107.
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Abstract   We compared the prophylactic efficacy of intravesical mitomycin C with bacillus Calmette-Guerin instillatian in the high risk superficial bladder tumor patients. Recurrent, grade III, multiple (more than 3) or large (more than 3 cm) stage Ta or Tl tumors were included. Thirty patients were treated with 8 weekly instillation of 40 mg of mitomycin C and 20 with 6 weekly instillation of 120 mg of BCG, Thirty six patients were selected as a control group. The patients and tumor characteristics in three groups were comparable (p> 0. 05). In control group, the one year recurrence rate and recurrences per 100 patient's months were 74% and 9 43. In mitomycin C group, those were 70% and 8.53, which was not statistically different from the control group. But in BCG group, the results were 45% and 5.85, which showed significantly better prophylactic effect than mitomycin C and control groups (p<0.05). The recurrence free curve using Kaplan-Meier method of BCG group showed higher recurrence free pattern than that of mitomycin C and control groups (p<0.05). We concluded tentatively from these observation that intravesical BCG instillation is superior to mitomycin C and cantrol groups in patients with high risk superficial bladder tumor in short term followup period.
저 자   이은식(Eun Sik Lee),박문수(Moon Soo Park),이종욱(Chong Wook Lee)